SOURCE OF TISSUE: Skin, left arm, excision

CLINICAL DIAGNOSIS:  238.2

SPECIMEN SOURCE:  LEFT ARM SKIN LESION

GROSS DESCRIPTION:  Received in formalin is a skin ellipse with underlying soft tissue measuring 2.2 x 1.2 x 0.3. The skin surface is tan gray to brown and demonstrates a centrally located raised, slightly ulcerated lesion measuring 0.8 cm in greatest dimension. The surgical margin is inked black. The specimen is serially sectioned and submitted as:
A)  tips, both tips up
B-C)  remainder of lesion

MICROSCOPIC DESCRIPTION:  The epidermis, centrally, is hyperkeratotic. The stratum corneum in this area is largely composed of compact orthokeratin. Beneath this areas [SIC], there is a proliferation of atypical-appearing squamous cells which infiltrate into the underlying dermis forming a vague cup-shaped configuration. These atypical squamous cells do extend to the deep resection margin. They have enlarged nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. The surrounding dermis exhibits marked solar elastosis.

PATHOLOGICAL DIAGNOSIS:  SKIN, LEFT ARM BIOPSY:
    INFLITRATING SQUAMOUS CELL CARCINOMA, WELL DIFFERENTIATED, KERATOACANTHOMA TYPE, BIOPSY

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